Enantioselective construction of functionalized oxazoles <i>via</i> anionic stereogenic-at-cobalt(<scp>iii</scp>) complex-catalyzed Ugi-4CR/Wittig reaction sequences

A one-pot synthesis of chiral multifunctional oxazole frameworks is accomplished <i>via</i> a cascade reaction involving an anionic stereogenic cobalt(III) complex-catalyzed enantioselective Ugi four-component/Wittig process. This approach tolerates a complex reaction system that includes aldehydes, amines, carboxylic acids, and isocyano-(triphenylphosphoranylidene)acetates, yielding chiral 2,4,5-trisubstituted oxazoles with good enantioselectivities (up to 93 : 7 er).