Comparative study of the effects of baicalin and probenecid on microRNA expression profiles in porcine aortic vascular endothelial cells infected by Glaesserella parasuis
Our findings suggested that baicalin and probenecid regulated miRNAs associated with vascular inflammation and damage, but showed different modulation patterns. This report provided the first comparison of the effects of baicalin and probenecid on G. parasuis-infected PAVECs, and might aid in the development of novel biomarkers and therapeutic targets to control G. parasuis infection.
Authors
- Chun Jimmie Ye (ORCID: https://orcid.org/0000-0001-6560-3783)
- Ling Guo (ORCID: https://orcid.org/0000-0002-5743-098X)
- Yaqiong Yang (ORCID: https://orcid.org/0000-0003-0826-656X)
- Peiyan Sun
- Yinsheng Qiu (ORCID: https://orcid.org/0000-0002-5884-6370)
- Bingbing Zong
- Jing He (ORCID: https://orcid.org/0000-0003-3339-482X)
- Linrong Yang
- Shulin Fu
Institutions
- Wuhan Polytechnic University (CN)
- Center of Hubei Cooperative Innovation for Emissions Trading System (CN)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1186/s12917-025-04702-2
- Primary Topic
- Calpain Protease Function and Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Wuhan Polytechnic University
- Hubei Key Laboratory of Animal Nutrition and Feed Science