Introduction of human m6Am methyltransferase PCIF1 facilitates the biosynthesis of terpenoids in Saccharomyces cerevisiae
This study presents a PCIF1-based metabolic engineering strategy that could serve as an effective approach for the optimization of terpene biosynthesis in yeast cell factories.
Authors
- Yanbing Shi (ORCID: https://orcid.org/0000-0003-4369-0825)
- Tianyue An (ORCID: https://orcid.org/0000-0002-7291-3752)
- Baochen Fan
- Defang Li (ORCID: https://orcid.org/0000-0003-4151-9151)
- Xiqin Liang
- Jun Wang (ORCID: https://orcid.org/0000-0002-4606-5585)
- Guoli Wang (ORCID: https://orcid.org/0000-0001-7390-3188)
- Qiusheng Zheng (ORCID: https://orcid.org/0000-0001-6413-9878)
- Mingkai Li (ORCID: https://orcid.org/0000-0001-5269-1331)
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Southwest Medical University (CN)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1186/s12934-025-02701-4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province