Inducing mononuclear cells of patients with CADASIL to construct a CSVD disease model
Reprogramming technology can be used to induce PBMCs to become iPSCs, and a CSVD disease model can be successfully constructed by culturing and differentiating the iPSCs into CADASIL vascular organoids. The NOTCH3 p.R141C mutation suppresses the vascular differentiation process in CADASIL.
Authors
- Wen-Hsiu Huang Ming-Che Chao
- Zhiqiang Wang (ORCID: https://orcid.org/0000-0002-5839-743X)
- Jianjian Yin
- Xiaoning Zhang
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Second Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1186/s40001-025-02491-w
- Citations
- 3
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Xinjiang Medical University
- Natural Science Foundation of Xinjiang