Neutrophil extracellular traps-mediated upregulation of HIF-1α promotes corneal neovascularization
Exposure to sodium hydroxide serves as a trigger for the induction of NETs formation. NETs mediated an up-regulation of HIF-1α, which subsequently promotes angiogenesis and inflammatory activation in HUVECs. Consequently, this process leads to an enhancement of corneal neovascularization and inflammatory response.
Authors
- Jianhai Bai
- Chunlian Huang (ORCID: https://orcid.org/0000-0001-7661-0962)
- Jing Wen (ORCID: https://orcid.org/0009-0001-4627-4598)
- Dan Zheng
- Xiao Shen (ORCID: https://orcid.org/0000-0002-5214-6293)
Institutions
- Taizhou Central Hospital (CN)
Publication Details
- Journal
- Tissue and Cell
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1016/j.tice.2025.102891
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.80