Multiplex Spatial Proteomic Analysis of HER2–Positive Breast Tumors Reveals Unique Molecular and Immunologic Features Associated With Treatment Response
ER-negative, HER2-positive breast cancer has unique molecular and immunologic features that may predict pCR after neoadjuvant HP. Validation of these potential biomarkers and composite biomarker analyses may guide design of future clinical trials.
Authors
- Roisín M. Connolly (ORCID: https://orcid.org/0000-0003-0056-1070)
- Jodi M. Carter (ORCID: https://orcid.org/0000-0002-5973-0732)
- E. Aubrey Thompson
- Lilja B. Sólnes (ORCID: https://orcid.org/0000-0002-2192-7425)
- Y. Ma (ORCID: https://orcid.org/0000-0002-3307-8029)
- Richard L. Wahl (ORCID: https://orcid.org/0000-0002-7306-2590)
- Jennifer M. Specht (ORCID: https://orcid.org/0000-0003-1484-2113)
- Antonio C. Wolff (ORCID: https://orcid.org/0000-0003-3734-1063)
- Ian E. Krop (ORCID: https://orcid.org/0000-0002-6380-5944)
- Rita Denbow (ORCID: https://orcid.org/0000-0002-6603-3863)
- Maeve Hennessy (ORCID: https://orcid.org/0000-0002-2369-3327)
- Ashley Cimino‐Mathews (ORCID: https://orcid.org/0000-0002-0638-7969)
- Lisa A. Carey (ORCID: https://orcid.org/0000-0003-2388-4649)
- Anna Maria Storniolo (ORCID: https://orcid.org/0000-0002-8701-7889)
- Vered Stearns (ORCID: https://orcid.org/0000-0003-4018-4708)
- Christos Vaklavas (ORCID: https://orcid.org/0000-0002-9919-2748)
- Edith A. Perez (ORCID: https://orcid.org/0000-0002-5037-6677)
- Eric P. Winer (ORCID: https://orcid.org/0000-0002-8819-1723)
- Jennifer M. Kachergus
- Mothaffar F. Rimawi (ORCID: https://orcid.org/0000-0002-4284-5656)
- Chiung‐Yu Huang (ORCID: https://orcid.org/0000-0003-2313-3562)
- Vandana G. Abramson (ORCID: https://orcid.org/0000-0002-6855-1322)
- Vicente Valero (ORCID: https://orcid.org/0000-0001-5913-7480)
- Jeffrey P. Leal (ORCID: https://orcid.org/0000-0002-8774-4541)
Institutions
- University of North Carolina at Chapel Hill (US)
- Indiana University Health (US)
- The University of Texas MD Anderson Cancer Center (US)
- Johns Hopkins University (US)
- University of Alberta (CA)
- University of California, San Francisco (US)
- Baylor College of Medicine (US)
- Vanderbilt University (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- University College Cork (IE)
- Yale Cancer Center (US)
- University of Alabama at Birmingham (US)
- Mayo Clinic in Florida (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Weill Cornell Medicine (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1200/po-24-00546
- Citations
- 1
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 1.36