A novel mechanism for A-to-I RNA-edited CYP1A1 in promoting cancer progression in NSCLC
Our findings highlight that the I462V A-to-I RNA editing event of CYP1A1 drives pulmonary carcinogenesis through inhibiting oxidative stress and suggest that the CYP1A1-HO-1-PI3K/Akt axis may be a potential therapeutic target for NSCLC.
Authors
- Ziqi Ding
- Xinru Xiao (ORCID: https://orcid.org/0009-0009-7149-2990)
- Zhipeng Wang (ORCID: https://orcid.org/0000-0002-7964-9288)
- Qian Zhang (ORCID: https://orcid.org/0000-0003-4928-3366)
- Zhiguang Liu (ORCID: https://orcid.org/0000-0003-3551-3829)
- Yanhua Huang (ORCID: https://orcid.org/0000-0002-5732-0203)
- Yan Wu (ORCID: https://orcid.org/0000-0002-0290-4084)
Institutions
- Shanghai Jiao Tong University (CN)
- Changzhou No.2 People's Hospital (CN)
- Changzhou Third People's Hospital (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1186/s11658-025-00718-6
- Citations
- 9
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- Nanjing Medical University