Integrative network analysis reveals novel moderators of Aβ-Tau interaction in Alzheimer's disease
These findings suggest that GPNMB + microglia moderate the Aβ-tau interaction in early AD and therefore are a novel therapeutic target. To facilitate further research, we have made the integrated network available as a visualization tool for the scientific community (URL: https://igcore.cloud/GerOmics/AlzPPMap ).
Authors
- Akihiro Kitani (ORCID: https://orcid.org/0009-0004-2220-8109)
- Yusuke Matsui (ORCID: https://orcid.org/0000-0003-3977-4313)
Institutions
- Nagoya University (JP)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1186/s13195-025-01705-x
- Citations
- 4
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- Japan Society for the Promotion of Science