Smart polymer prodrugs <i>via</i> responsive prodrug-initiated ring-opening polymerization of lactide for improved drug delivery
Smart polymer prodrugs, created <i>via</i> responsive prodrug-initiated controlled polymerization of lactide, demonstrated extremely high drug loading, tuneable stimuli-triggered drug release, and significant tumor growth inhibition and improved survival with minimal toxicity. This adaptable strategy can precisely tailor drugs' physicochemical properties for optimal therapeutic efficacy, demonstrating great promise for cancer treatment.
Authors
- Shiwei Fu (ORCID: https://orcid.org/0009-0004-3702-2163)
- Bowei Yang
- Ajay Zheng
- Nicholas Calzadilla
- Fuwu Zhang (ORCID: https://orcid.org/0000-0002-1928-3472)
- Xiao Zhang (ORCID: https://orcid.org/0000-0002-1820-9393)
- Victoria A A McKenzie
- Miao Zhang (ORCID: https://orcid.org/0000-0001-5490-1283)
- Qianqian Ni (ORCID: https://orcid.org/0000-0003-4230-5059)
- Bowen Zhao (ORCID: https://orcid.org/0000-0002-4440-079X)
Institutions
- University of Miami (US)
- National University of Singapore (SG)
- Université Bourgogne Franche-Comté (FR)
- Dr. John T. Macdonald Foundation (US)
- Sylvester Comprehensive Cancer Center (US)
- Florida Memorial University (US)
Publication Details
- Journal
- Nanoscale
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5nr00780a
- Citations
- 6
- Primary Topic
- biodegradable polymer synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 3.58
Funders
- University of Miami