Unraveling the mechanisms of propofol-induced psychological dependence: a multi-omics approach linked to gut microbiota in hippocampal function
These findings suggest that 75 mg/kg propofol has a significant mind-dependent effect on the biology of drug addiction through neuroactive ligand-receptor interaction pathways in conjunction with the tricarboxylic acid cycle, and the metabolic pathways of alanine, aspartate, and glutamate that may influence intestinal microbial changes through bidirectional signaling.
Authors
- Yuxin Lin (ORCID: https://orcid.org/0000-0001-6543-0317)
- Yu L. Lei (ORCID: https://orcid.org/0000-0002-9868-9824)
- Tianyun Wang (ORCID: https://orcid.org/0000-0001-5507-7505)
- Shoude Zhang (ORCID: https://orcid.org/0000-0002-1320-2248)
- Li Wang (ORCID: https://orcid.org/0000-0002-3276-8829)
- Haiyan Wang (ORCID: https://orcid.org/0000-0001-8728-0719)
- Zhijing Wu
- Qiong Wu (ORCID: https://orcid.org/0000-0001-9712-0647)
- Yudong Su
Institutions
- Qinghai University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-04-03
- DOI
- https://doi.org/10.3389/fmed.2025.1539467
- Citations
- 1
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.55