Metabolic Flexibility as a Candidate Mechanism for the Development of Postoperative Morbidity
Metabolic flexibility may be a pivotal factor in determining postoperative outcomes. Patients with greater metabolic adaptability had fewer complications and shorter hospitalization by 4 days on average. This suggests that preoperative metabolic conditioning-something potentially achieved by targeted prehabilitation-could be linked to surgical recovery. Future research should focus on prospective studies to confirm these relationships and explore underlying mechanisms. If confirmed, metabolic flexibility assessments could be integrated into routine preoperative evaluation to better predict and improve patient outcomes.
Authors
- Robert Stephens (ORCID: https://orcid.org/0000-0002-7510-1143)
- Nicholas Tetlow (ORCID: https://orcid.org/0000-0002-4907-9018)
- Mervyn Singer (ORCID: https://orcid.org/0000-0002-1042-6350)
- Ramani Moonesinghe (ORCID: https://orcid.org/0000-0002-6730-5824)
- Evangelos B. Mazomenos (ORCID: https://orcid.org/0000-0003-0357-5996)
- DANIEL S. MARTIN (ORCID: https://orcid.org/0000-0001-6220-8235)
- Pietro Arina (ORCID: https://orcid.org/0000-0002-2080-5274)
- John Whittle (ORCID: https://orcid.org/0000-0002-3859-679X)
- Amy Dewar (ORCID: https://orcid.org/0000-0001-7960-0866)
- Maciej R. Kaczorek
- Davide Ferrari (ORCID: https://orcid.org/0000-0002-4777-7234)
Institutions
- National Health Service (GB)
- Engineering and Physical Sciences Research Council (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- King's College London (GB)
- Bury College (GB)
- University College London (GB)
- University of Plymouth (GB)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1213/ane.0000000000007494
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00