Malignant Transformation of a Vestibular Schwannoma Without Previous Radiation Exposure: Illustrative Case and Literature Review
A total of 11 cases, including ours, have appropriate S-100 immunochemical reactivity to confirm malignant transformation. Due to the limited number of reported cases of MPNST arising from VS without prior irradiation, information regarding pathogenesis and pathological diagnosis is scarce. We provide valuable additions to the literature, including next-generation sequencing data, to identify potentially targetable genetic changes and help elucidate the pathogenesis of MPNST.
Authors
- J. Christopher Fowler (ORCID: https://orcid.org/0000-0001-8369-1051)
- Kar‐Ming Fung (ORCID: https://orcid.org/0000-0002-4623-9469)
- William Wu (ORCID: https://orcid.org/0000-0002-3851-036X)
- Kishore Balasubramanian (ORCID: https://orcid.org/0000-0002-7271-7022)
- Piao Zhe
- Chao Li (ORCID: https://orcid.org/0000-0002-4751-4194)
Institutions
- Texas A&M Health Science Center (US)
- Hartford Hospital (US)
- Kaiser Permanente Fontana Medical Center (US)
- Hartford Financial Services (United States)
- University of Oklahoma Health Sciences Center (US)
Publication Details
- Journal
- Journal of Neurological Surgery Reports
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1055/a-2547-5320
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 0.00