Gantry-based pencil beam scanning proton therapy for uveal melanoma: IMPT versus proton arc therapy
This is a novel report on proton arc for ocular tumors and gantry-based multifield PBS proton treatment for these tumors. This study demonstrated that both modalities can meet the clinical goals. The IMPT is currently clinically implanted, and 2-field non-coplanar proton arc plans can achieve comparable dosimetric metrics to those of IMPT plans when the deliver technique is matured.
Authors
- Jasmine H. Francis (ORCID: https://orcid.org/0000-0002-7637-3108)
- Sheng Huang (ORCID: https://orcid.org/0000-0001-9481-3579)
- Peter J. Park (ORCID: https://orcid.org/0000-0001-9378-960X)
- Christopher A. Barker (ORCID: https://orcid.org/0000-0003-1882-1088)
- Jun Zhou (ORCID: https://orcid.org/0000-0002-6078-9424)
- Qing Chen (ORCID: https://orcid.org/0000-0003-3106-9281)
- David H. Abramson (ORCID: https://orcid.org/0000-0002-0118-6391)
- Yunjie Yang (ORCID: https://orcid.org/0000-0002-8670-955X)
- Minglei Kang (ORCID: https://orcid.org/0000-0002-5054-7587)
- Xuanfeng Ding (ORCID: https://orcid.org/0000-0002-1733-6278)
- M. A. Vermeulen (ORCID: https://orcid.org/0000-0001-6353-4729)
- Charles B Simone
- Hang Qi
- Lei Hu (ORCID: https://orcid.org/0000-0003-0715-1218)
- Huifang Zhai (ORCID: https://orcid.org/0000-0002-9777-1447)
- Haibo Lin (ORCID: https://orcid.org/0000-0001-8779-7849)
- Yen-Po Lee
- Francis T. S. Yu
- Andy Shim
Institutions
- Albert Einstein College of Medicine (US)
- Memorial Sloan Kettering Cancer Center (US)
- Emory University (US)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Virginia Cancer Institute (US)
- New York Proton Center (US)
- Beaumont Hospital, Royal Oak (US)
- University of Iowa Health Care (US)
- Beaumont Hospital, Troy (US)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1186/s13014-025-02621-y
- Citations
- 1
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- Varian Medical Systems
- National Institutes of Health
- National Cancer Institute