Increased Global and Regional Connectivity in Propofol-induced Unconsciousness: Human Intracranial Electroencephalography Study
Propofol anesthesia suppresses cortical activity and induces oscillatory changes characterized by increased delta power and decreased high gamma power. These changes are accompanied by increased functional connectivity and reduced network complexity and efficiency. These changes limit the brain's ability to generate a diverse repertoire of activity, ultimately leading to unconsciousness. Posterior connectivity, which showed high accuracy in predicting conscious states, would be crucial for sustaining consciousness.
Authors
- June Sic Kim (ORCID: https://orcid.org/0000-0002-9659-4944)
- Jii Kwon (ORCID: https://orcid.org/0000-0001-7674-6085)
- Yunhee Choi (ORCID: https://orcid.org/0000-0001-5305-1803)
- Seokhyun Lee (ORCID: https://orcid.org/0000-0003-1436-2865)
- Hee‐Pyoung Park (ORCID: https://orcid.org/0000-0002-4772-0780)
- Mi Kyung Choe (ORCID: https://orcid.org/0000-0002-6845-176X)
- Chun Kee Chung (ORCID: https://orcid.org/0000-0003-3485-2327)
- Seung‐Hyun Jin (ORCID: https://orcid.org/0000-0002-3883-9608)
Institutions
- Seoul National University (KR)
- Korea University (KR)
- Seoul National University Hospital (KR)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1097/aln.0000000000005479
- Citations
- 1
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 2.19