o8G-modified circKIAA1797 promotes lung cancer development by inhibiting cuproptosis
This study revealed the presence of the o8G modification in circKIAA1797, which plays an important role in the development of lung cancer. circKIAA1797 can inhibit cuproptosis by inhibiting key cuproptosis proteins and promoting mPTP closure, ultimately promoting the development of lung cancer. This study provides not only a new theoretical basis for an in-depth understanding of the molecular mechanisms of lung cancer development but also a potential target for lung cancer treatment.
Authors
- Aruo Nan (ORCID: https://orcid.org/0000-0003-0351-8561)
- Xiaodong Zhou (ORCID: https://orcid.org/0000-0001-8198-5902)
- Wenyi Peng (ORCID: https://orcid.org/0000-0001-7699-6850)
- Deqing Li
- Haotian Xu (ORCID: https://orcid.org/0000-0003-1673-6779)
- Yihong Gao (ORCID: https://orcid.org/0000-0002-9293-4075)
- Xingcai Chen (ORCID: https://orcid.org/0000-0002-9489-5014)
- Gang Li (ORCID: https://orcid.org/0000-0002-3981-2239)
- Ruirui Zhang (ORCID: https://orcid.org/0000-0001-8928-4238)
- Jiaxi Wu
- Qingyun Zhao
- Shengyi Yuan
- Dunyu Cai
Institutions
- Guangxi Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1186/s13046-025-03365-z
- Citations
- 10
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 8.06
Funders
- National Natural Science Foundation of China