Synthesis of novel antimicrobial 7-But-2-ynyl-1-(substituted-benzyl)-3-methyl-8-morpholin-4-yl-1H -purine-2,6-diones

In this study, we synthesized 7-But-2-ynyl-3-methyl-8-morpholin-4-yl-3,4,5,7-tetrahydro-purine-2,6-diones from 8-Bromo-7-but-2-ynyl-3-methyl-3,4,5,7-tetrahydro-purine-2,6-dione and morpholine using lithium hydroxide and DMSO as a medium. We further coupled 7-But-2-ynyl-3-methyl-8-morpholin-4-yl-3,4,5,7-tetrahydro-purine-2,6-dione with different halo compounds to obtain various derivatives. These synthesized compounds were then tested for their antimicrobial activities against S. aureus , B. subtilis , S. typhi , and E. coli . Synthesis of 7-But-2-ynyl-1-(substituted-benzyl)-3-methyl-8-morpholin-4-yl-3,4,5,7-tetrahydro-purine-2,6-dione (5a-h) . Biological activity: The synthesized compounds 5a - 5 h, show promising in vitro antimicrobial activities against S. aureus bacteria compared to Streptomycin.