Improving diagnostic accuracy of indeterminate thyroid fine needle aspiration using results of ultrasound examination, cyclin D1 immunostaining and molecular testing
The addition of cyclin D1 immunocytochemistry or a simple gene panel test, either alone or in combination, significantly improves the limited diagnostic utility of merely repeating the C-TIRADS score in thyroid nodules with indeterminate cytology. Laboratories should integrate these tests to effectively manage uncertain thyroid nodules and reduce diagnostic ambiguity.
Authors
- Di Jing (ORCID: https://orcid.org/0000-0002-2227-389X)
- Songtao Hu (ORCID: https://orcid.org/0000-0001-7549-1762)
- Kan Gao (ORCID: https://orcid.org/0000-0001-5815-6348)
- Rongming Chen
- Mengge Wang (ORCID: https://orcid.org/0009-0003-5922-0243)
- Feiliang Wang (ORCID: https://orcid.org/0000-0002-1630-3204)
- Shurong He (ORCID: https://orcid.org/0000-0001-5453-9157)
- Mulan Jin (ORCID: https://orcid.org/0000-0001-6043-5020)
- Dongge Liu
- Jingxin Zhang (ORCID: https://orcid.org/0000-0001-7902-1880)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Beijing Shijingshan Hospital (CN)
- Third People's Hospital of Hefei (CN)
- Beijing Chaoyang Emergency Medical Center (CN)
- Hefei First People's Hospital (CN)
Publication Details
- Journal
- Acta Cytologica
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1159/000545319
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00