The colorectal cancer microenvironment governs clinical behaviors and chemotherapy response
• Decellularized colorectal patient-derived scaffolds retain key cancer progression traits imprinted in the primary cancer niche. • Scaffold proteins and gene expression changes in adapting cancer cells are linked to clinical response to 5FU chemotherapy. • Preclinical scaffold techniques in precision medicine can reveal cancer-specific and treatment predictive information.
Authors
- Simona Salerno (ORCID: https://orcid.org/0000-0003-3472-4966)
- Anders Ståhlberg (ORCID: https://orcid.org/0000-0003-4243-0191)
- Göran Landberg (ORCID: https://orcid.org/0000-0001-9004-9403)
- André Holdfeldt (ORCID: https://orcid.org/0000-0001-9357-449X)
- Elinor Bexe Lindskog (ORCID: https://orcid.org/0000-0003-1466-1486)
Institutions
- Sahlgrenska University Hospital (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Cancer Letters
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1016/j.canlet.2025.217687
- Citations
- 3
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.14