NLRP3 Mediates NOXs-Induced Iron Overload and Inflammation but Not Oxidative Damage in Colons of DSS-Treated Mice
To our knowledge, this work is the first to reveal that NLRP3 mediates NOXs-induced colonic iron overload and inflammation rather than oxidative damage in ulcerative colitis murine model, suggesting that the NOXs might promote ulcerative colitis by inducing colonic iron overload and macrophage infiltration dependent or partially dependent on NLRP3, as well as oxidative damage independent of NLRP3, which imply that both NOXs and NLRP3 are attractive targets for anti-colitis therapy.
Authors
- Qingqing Zheng (ORCID: https://orcid.org/0000-0001-7726-1901)
- Linna Yu (ORCID: https://orcid.org/0000-0001-6143-3676)
- Zhengji Song (ORCID: https://orcid.org/0000-0002-6297-0497)
- Jialong Qi (ORCID: https://orcid.org/0000-0001-6361-7479)
- Meng Wang (ORCID: https://orcid.org/0000-0002-3094-7735)
- Yunjiao Zhou
Institutions
- Kunming University of Science and Technology (CN)
- First People's Hospital of Yunnan Province (CN)
- Guangzhou Women and Children Medical Center (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/jir.s509168
- Citations
- 3
- Primary Topic
- Hydrogen's biological and therapeutic effects
- Type
- article
- Field-Weighted Citation Impact
- 6.02