Clinics and genetics of hyperhemolysis syndrome in patients with sickle cell disease
HHS primarily affects adolescents and young adults with RBC alloantibodies, often following episodic transfusions. Genetic variations in STAT5B and the IRF7-PHRF1 region suggest that the B-cell receptor signaling pathway, which is essential for B-cell differentiation, may play a critical role in HHS pathophysiology.
Authors
- Shannon Kelly (ORCID: https://orcid.org/0000-0003-2049-3992)
- Álvaro Antônio Bandeira Ferraz (ORCID: https://orcid.org/0000-0002-3832-3927)
- Mina Cintho Ozahata (ORCID: https://orcid.org/0000-0002-1272-2380)
- André Rolim Belisário (ORCID: https://orcid.org/0000-0003-0166-4258)
- Carla Luana Dinardo (ORCID: https://orcid.org/0000-0002-0453-7863)
- Brian Custer (ORCID: https://orcid.org/0000-0001-6251-366X)
- Carolina Miranda (ORCID: https://orcid.org/0000-0001-8763-9576)
- Éster Cerdeira Sabino (ORCID: https://orcid.org/0000-0003-2623-5126)
- Isabel Cristina Gomes (ORCID: https://orcid.org/0000-0002-5549-3426)
- Luiz Amorim
- Barbara Malta
Institutions
- Universidade Federal de Minas Gerais (BR)
- Universidade de São Paulo (BR)
- Pacific Research Institute (US)
- Hemorio (BR)
- Vitalant (US)
- UCSF Benioff Children's Hospital (US)
- Fundação Hemopa (BR)
- Fundação Centro de Hematologia e Hemoterapia de Minas Gerais (BR)
- Fundação Pró-Sangue Hemocentro de São Paulo (BR)
Publication Details
- Journal
- Transfusion
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1111/trf.18232
- Citations
- 1
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- National Heart, Lung, and Blood Institute