The role of preeclampsia in breast cancer risk: insights from Mendelian randomization study

This MR study, supported by a robust meta-analysis, suggests that preeclampsia may have a protective effect against breast cancer, especially ER-negative breast cancer. However, to firmly establish this relationship, additional prospective studies with larger populations are warranted. Moreover, further exploration of the biological mechanisms underlying this potential association is needed through both in vitro and in vivo research.