Time Course of Kidney Injury Biomarkers in Children With Septic Shock: Nested Cohort Study Within the Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis Trial
Although kidney injury biomarkers mirrored serum creatinine in children with septic shock, elevated Ur-NGAL identified a subset with subclinical AKI with fewer hospital-free days despite no/stage 1 AKI by creatinine. Children receiving greater than 100 mL/kg fluid had greater odds of early and persistently elevated Ur-NGAL, suggesting high fluid volumes may perpetuate initial kidney damage.
Authors
- Fran Balamuth (ORCID: https://orcid.org/0000-0003-3709-7160)
- Elliot J. Long (ORCID: https://orcid.org/0000-0003-0225-7953)
- Jing Yang Huang (ORCID: https://orcid.org/0000-0002-6133-6988)
- Benjamin L. Laskin (ORCID: https://orcid.org/0000-0002-9994-8509)
- Stuart R. Dalziel (ORCID: https://orcid.org/0000-0003-0522-9579)
- Graham C. Thompson (ORCID: https://orcid.org/0000-0002-6781-4186)
- Robert W. Hickey (ORCID: https://orcid.org/0000-0002-7708-9512)
- Daniel Singleton
- Scott L. Weiss (ORCID: https://orcid.org/0000-0002-7040-3281)
- Franz E Babl (ORCID: https://orcid.org/0000-0002-1107-2187)
- Michelle D. Eckerle (ORCID: https://orcid.org/0000-0002-7716-288X)
- Elena Tsemberis
- Amanda Artis (ORCID: https://orcid.org/0000-0002-7278-2326)
- Akbar Vohra (ORCID: https://orcid.org/0000-0001-8148-8607)
- Christopher Hickey
- Nathan Kuppermann (ORCID: https://orcid.org/0000-0002-7854-4943)
- Katie Hayes (ORCID: https://orcid.org/0000-0001-8113-5828)
- Julie C. Fitzgerald (ORCID: https://orcid.org/0000-0002-7627-1689)
- Ana Cristina Viana Campos (ORCID: https://orcid.org/0000-0003-0596-6632)
- Stephen B. Freedman (ORCID: https://orcid.org/0000-0003-2319-6192)
- Kristen C. Lau (ORCID: https://orcid.org/0000-0001-7743-4622)
- Ruchi Singh (ORCID: https://orcid.org/0000-0001-8094-4703)
- Emem Kierian
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Royal Children's Hospital (AU)
- Children's Hospital of Philadelphia (US)
- Thomas Jefferson University (US)
- University of Auckland (NZ)
- The University of Melbourne (AU)
- University of Calgary (CA)
- George Washington University (US)
- Community Health Systems - Dupont Hospital (US)
- Alberta Children's Hospital (CA)
- Nemours Children's Health System (US)
- Auckland District Health Board (NZ)
- Children's Hospital of Pittsburgh (US)
- Starship Children's Health (NZ)
- Murdoch Children's Research Institute (AU)
- University of Pennsylvania (US)
Publication Details
- Journal
- Pediatric Critical Care Medicine
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1097/pcc.0000000000003737
- Citations
- 8
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 11.45