Irisin Alleviates Impaired Mitochondrial Fusion via Enhancing PKA/SIRT3/mTOR Pathway in Hepatic Steatosis
Our results demonstrate the protective role of irisin in alleviating hepatic steatosis by regulating mitochondrial dynamics. These findings provide valuable evidence of the antisteatogenic mechanisms of irisin and its therapeutic potential for MASLD management.
Authors
- Yunzhi Ni (ORCID: https://orcid.org/0000-0003-2453-2522)
- Anran Ma (ORCID: https://orcid.org/0000-0003-1831-0851)
- Jia Li (ORCID: https://orcid.org/0000-0002-3821-9919)
- Yue Zhou (ORCID: https://orcid.org/0009-0008-9302-3223)
- Yongsheng Chang (ORCID: https://orcid.org/0000-0002-7846-8127)
- Di Wu (ORCID: https://orcid.org/0000-0003-4941-563X)
- Na Zhang (ORCID: https://orcid.org/0000-0001-6978-2731)
- Li Zhang (ORCID: https://orcid.org/0000-0003-2259-0817)
- Qinghua Wang (ORCID: https://orcid.org/0000-0002-5328-7397)
- Zhihong Wang (ORCID: https://orcid.org/0000-0003-3196-1739)
- Ying Zhao (ORCID: https://orcid.org/0009-0009-5182-8100)
Institutions
- Fudan University (CN)
- Huashan Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Gastroenterology and Hepatology
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1111/jgh.16950
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China