Metabolomic network reveals novel biomarkers for type 2 diabetes mellitus in the <scp>UK</scp> Biobank study
By constructing a metabolic network that captures the complex interrelationships among circulating metabolites, our study identified total triglycerides and large HDL cholesterol as central hubs in the T2DM risk metabolome network. BCAA and GlycA emerged as alarm indicators for pre-T2DM individuals and females, respectively. Network analysis not only elucidates the topological functional roles of biomarkers but also addresses the limitations of false positives and collinearity in single-metabolite studies, offering insights for metabolic pathway research and precision interventions.
Authors
- Jiahao Liu (ORCID: https://orcid.org/0000-0002-9979-5805)
- Zhuoting Zhu (ORCID: https://orcid.org/0000-0002-9897-1192)
- Beiou Zhang (ORCID: https://orcid.org/0009-0004-9085-9739)
- Catherine Jan (ORCID: https://orcid.org/0000-0001-7383-8208)
- Ruiye Chen
- Wenyi Hu (ORCID: https://orcid.org/0000-0001-7366-3874)
- Mayinuer Yusufu (ORCID: https://orcid.org/0000-0002-4860-0318)
- Xianwen Shang (ORCID: https://orcid.org/0000-0002-2362-3222)
- Yutong Chen (ORCID: https://orcid.org/0000-0003-4234-8139)
- Lei Zhang (ORCID: https://orcid.org/0000-0003-2343-084X)
- Xueli Zhang (ORCID: https://orcid.org/0000-0001-8306-0639)
- Wentao Tang (ORCID: https://orcid.org/0000-0003-0816-2322)
- Mingguang He
- Yujie Wang (ORCID: https://orcid.org/0009-0000-9102-5497)
- Li Li (ORCID: https://orcid.org/0000-0002-9428-1960)
Institutions
- The University of Sydney (AU)
- Sun Yat-sen University (CN)
- The University of Melbourne (AU)
- Melbourne Sexual Health Centre (AU)
- Centre for Eye Research Australia (AU)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Alfred Health (AU)
- Monash University (AU)
- Victoria University (AU)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1111/dom.16351
- Citations
- 7
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Australian Government
- Monash University
- State Key Laboratory of Ophthalmology
- National Health and Medical Research Council