Cancer Accumulation and Anticancer Activity of “<scp>CROX</scp> (Cluster Regulation of <scp>RUNX</scp>)” <scp>PIP</scp> in <scp><i>HER2</i></scp>‐Positive Gastric Cancer Evaluated by Chicken Egg Cancer Model
Our present findings strongly suggest that Chb-M' preferentially accumulates in cancer to suppress its growth, and the CAM model might serve as a valuable and promising platform to rapidly assess the cancer uptake and anti-cancer efficacy of various PI polyamide-based drug candidates.
Authors
- Jason Lin (ORCID: https://orcid.org/0000-0002-8086-3185)
- Yasuhiko Kamikubo (ORCID: https://orcid.org/0000-0003-2761-8508)
- Toshinori Ozaki (ORCID: https://orcid.org/0000-0002-1612-7394)
- Kazuhiro Okumura (ORCID: https://orcid.org/0000-0002-4980-3125)
- Hiroshi Sugiyama (ORCID: https://orcid.org/0000-0001-8923-5946)
- Yasutoshi Tatsumi (ORCID: https://orcid.org/0000-0003-2646-7410)
- Takayoshi Watanabe (ORCID: https://orcid.org/0000-0001-8203-4412)
- Tatsuya Masuda (ORCID: https://orcid.org/0009-0003-7717-2994)
Institutions
- Kyoto University (JP)
- Chiba Cancer Center (JP)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/cam4.70845
- Citations
- 2
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science