Effects of weight loss on testosterone, sex hormone‐binding globulin, adiposity, and insulin sensitivity in women and men
BioA testosterone was associated with Rd, positively in men and negatively in women. Weight loss reduced BioA testosterone in women; however, individual changes were associated with improved Rd in men. SHBG was a better correlate of improved Rd in women. Additional studies should identify mechanisms that drive sex differences and interventions that modify testosterone, reduce adiposity, and improve Rd across both sexes.
Authors
- David E. Kelley (ORCID: https://orcid.org/0000-0002-0143-0956)
- Bret H. Goodpaster (ORCID: https://orcid.org/0000-0003-1275-5147)
- Justine M. Mucinski (ORCID: https://orcid.org/0000-0003-4432-6638)
- Stephen J. Winters (ORCID: https://orcid.org/0000-0003-3721-7388)
Institutions
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- University of Louisville (US)
- AdventHealth Orlando (US)
- Translational Research Institute for Metabolism and Diabetes (US)
Publication Details
- Journal
- Obesity
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/oby.24269
- Citations
- 1
- Primary Topic
- Hormonal and reproductive studies
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases