Reversal of Factor Xa Inhibitor-Related Intracranial Hemorrhage: A Multicenter, Retrospective, Observational Study Comparing the Efficacy and Safety of Andexanet and Prothrombin Complex Concentrates
Despite statistically higher odds of achieving hemostatic efficacy with andexanet, we also observed higher odds of a TE with no difference in discharge outcomes observed between groups. When those with more severe neurologic injuries were excluded, efficacy and safety outcomes were similar between treatments.
Authors
- Philip E. Tobias (ORCID: https://orcid.org/0000-0001-9904-3999)
- Aaron M. Cook (ORCID: https://orcid.org/0000-0001-8539-902X)
- G. Morgan Jones (ORCID: https://orcid.org/0000-0002-3224-1031)
- Nicholas Panos (ORCID: https://orcid.org/0000-0002-9868-699X)
- Gary D. Peksa (ORCID: https://orcid.org/0000-0003-3625-8137)
- Joshua M. DeMott (ORCID: https://orcid.org/0000-0002-2151-4049)
- Ivan Da Silva (ORCID: https://orcid.org/0000-0001-8572-9631)
- Sayona John (ORCID: https://orcid.org/0000-0002-2133-7265)
Institutions
- Rush University Medical Center (US)
- Apple (Israel) (IL)
- University of Kentucky (US)
- University of Tennessee Health Science Center (US)
- University of Florida (US)
- Potato Research Institute (CZ)
- Florida College (US)
Publication Details
- Journal
- Critical Care Medicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1097/ccm.0000000000006656
- Citations
- 7
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 9.72