Functional vs Structural Cortical Deficit Pattern Biomarkers for Major Depressive Disorder
Results of this case-control study suggest that the ReHo MDD deficit pattern reflected cortical hypoperfusion and was regionally specific in MDD. ReHo-based RVI may serve as a sensitive functional biomarker for MDD.
Authors
- Jessica A. Turner (ORCID: https://orcid.org/0000-0003-0076-8434)
- Nicole R. Karcher (ORCID: https://orcid.org/0000-0001-5887-5529)
- Si Gao (ORCID: https://orcid.org/0000-0002-4473-1142)
- Neda Jahanshad (ORCID: https://orcid.org/0000-0003-4401-8950)
- Braxton D. Mitchell (ORCID: https://orcid.org/0000-0003-4920-4744)
- Hongjie Ke
- Demetrio Labate (ORCID: https://orcid.org/0000-0002-9718-789X)
- Xiaoming Du (ORCID: https://orcid.org/0000-0001-7206-5282)
- Tianzhou Ma (ORCID: https://orcid.org/0000-0003-3605-0811)
- Danny J.J. Wang (ORCID: https://orcid.org/0000-0002-0840-7062)
- Bhim M. Adhikari (ORCID: https://orcid.org/0000-0003-1164-0989)
- Robert Azencott
- Yizhou Ma (ORCID: https://orcid.org/0000-0002-2775-5660)
- Jair C. Soares (ORCID: https://orcid.org/0000-0002-5466-5628)
- Theo G.M. van Erp (ORCID: https://orcid.org/0000-0002-2465-2797)
- David B. Keator (ORCID: https://orcid.org/0000-0001-5281-5576)
- Shuo Chen (ORCID: https://orcid.org/0000-0002-7990-4947)
- Paul M. Thompson (ORCID: https://orcid.org/0000-0002-4720-8867)
- L. Elliot Hong (ORCID: https://orcid.org/0000-0002-2705-2076)
- Peter Kochunov
- Daniel Amen
- Yewen Huang
- Hussain Syed
- William Burroughs
Institutions
- University of Southern California (US)
- University of Maryland, Baltimore (US)
- University of California, Irvine (US)
- Washington University in St. Louis (US)
- Amen Clinics (US)
- University of Houston (US)
- The Ohio State University (US)
- University of Maryland, College Park (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- JAMA Psychiatry
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1001/jamapsychiatry.2025.0192
- Citations
- 9
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 12.88
Funders
- University of Southern California
- Ohio State University
- University of California, Irvine
- NIH Clinical Center