Intranasal pramlintide matches intraperitoneal effects on food intake and gastric emptying in mice
Although intranasal pramlintide is not comparable in magnitude to intraperitoneal administration at an equivalent administered dose, our evidence corroborates the development of novel intranasal formulations destined to overpass the bioavailability issue and potentially serve as an alternative route.
Authors
- Carine Zuglianello (ORCID: https://orcid.org/0000-0002-8069-8300)
- Mariele Paludetto Sanches (ORCID: https://orcid.org/0000-0003-2075-0477)
- Lı́cio A. Velloso (ORCID: https://orcid.org/0000-0002-4806-7218)
- Joseane Morari (ORCID: https://orcid.org/0000-0002-0728-4283)
- Elenara Lemos‐Senna (ORCID: https://orcid.org/0000-0002-3642-4468)
- Alex Rafacho (ORCID: https://orcid.org/0000-0002-8637-6097)
- Milena S Almeida (ORCID: https://orcid.org/0000-0003-2262-0035)
- Natália Stinghen Tonet (ORCID: https://orcid.org/0000-0001-8193-5358)
Institutions
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Department of Physiological Sciences (RU)
- Engene (Brazil) (BR)
- Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (BR)
Publication Details
- Journal
- Endocrine
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1007/s12020-025-04220-z
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina