Impaired LTB4-induced neutrophil chemotactic directionality in myelodysplastic neoplasms patients
MDS patients face a heightened risk of infection, potentially attributed to impaired neutrophil chemotactic speed and directionality, alongside compromised ROS and NAP activity. Notably, chemotactic directionality emerged as a pivotal factor correlated with antimicrobial therapy. These insights hold significant clinical implications for managing infections in MDS patients, underscoring the importance of targeting specific neutrophil defects for more effective therapeutic strategies.
Authors
- Zonghong Shao
- Hongzhao Li (ORCID: https://orcid.org/0000-0002-1587-8866)
- Huaquan Wang (ORCID: https://orcid.org/0000-0003-2402-2717)
- Liyan Yang (ORCID: https://orcid.org/0009-0003-8752-8915)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-7800-3189)
- Zhe Zhang (ORCID: https://orcid.org/0000-0003-2365-2362)
- Yumei Liu (ORCID: https://orcid.org/0009-0004-5986-4943)
- Xinyan Xie
- Hong Liu (ORCID: https://orcid.org/0000-0002-9687-6490)
Institutions
- Tianjin Medical University General Hospital (CN)
- Tianjin Children's Hospital (CN)
Publication Details
- Journal
- Hematology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1080/16078454.2025.2483551
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Tianjin Municipal Education Commission