Activation of autophagy mediated by PI3K/Akt/mTOR signalling cascade alleviates impaired adipose‐derived stem cell osteogenesis in a diabetic microenvironment
AGEs decreased the osteogenesis of ASCs by activating PI3K/Akt/mTOR signalling cascade and blocking autophagic flux. Autophagy induced by blocking the PI3K/Akt/mTOR signalling cascade could rescue the negative influences of ASCs in diabetic environment and provide a potential therapeutic strategy for bone renewal in individuals with DOP.
Authors
- Fangzhi Lou
- Shi Shou Lu (ORCID: https://orcid.org/0000-0002-8111-2746)
- Shuanglin Peng (ORCID: https://orcid.org/0000-0001-8128-7602)
- Qing Li (ORCID: https://orcid.org/0000-0002-7930-2145)
- Qilin Li (ORCID: https://orcid.org/0009-0000-3791-4250)
- Ting Fu (ORCID: https://orcid.org/0000-0001-8622-0837)
- Tianli Wu (ORCID: https://orcid.org/0000-0001-7881-8812)
- Pengcheng Rao
- Jingang Xiao
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- People's Hospital of Shiyan (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/bph.70016
- Citations
- 10
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 13.54
Funders
- National Natural Science Foundation of China