Dolutegravir plus lamivudine downregulates cellular stress responses vs. three-drug HIV regimens
Reducing NRTIs in DTG-based 2DR, particularly by omitting ABC or TAF/TDF, suggests decreased activation of stress response and immune-related pathways. Importantly, the functional capacity of circulating immune cells remains largely unchanged between 2DR and 3DR.
Authors
- W Vos
- Willem L. Blok
- Leo A. B. Joosten (ORCID: https://orcid.org/0000-0001-6166-9830)
- Janneke E. Stalenhoef (ORCID: https://orcid.org/0000-0003-1486-3045)
- Marc J. T. Blaauw (ORCID: https://orcid.org/0000-0002-5694-5877)
- Albert L. Groenendijk (ORCID: https://orcid.org/0000-0002-2072-2532)
- Louise E. van Eekeren (ORCID: https://orcid.org/0000-0001-6905-1891)
- Adriana Navas (ORCID: https://orcid.org/0000-0001-6519-2486)
- Nadira Vadaq (ORCID: https://orcid.org/0000-0002-1746-8844)
- Jan van Lunzen
- Lambert van den Heuvel
- Mihai G. Netea (ORCID: https://orcid.org/0000-0003-2421-6052)
- Victoria Rios-Vazquez
Institutions
- University of Bonn (DE)
- Radboud University Nijmegen (NL)
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- OLVG (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- GGD Amsterdam (NL)
- Elisabeth-TweeSteden Ziekenhuis (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- AIDS
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1097/qad.0000000000004198
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Radboud Universitair Medisch Centrum