FABP4 expression in neutrophils as a predictor of sepsis and SI-ARDS based on BALF transcriptome and peripheral blood validation
The downregulation of FABP4 in neutrophils was found to inhibit apoptosis through the activation of the PI3K/AKT signaling pathway. Importantly, the expression level of FABP4 in neutrophil emerged as a prognostic indicator for sepsis and SI-ARDS patients, suggesting its potential utility in clinical decision-making to address the challenges posed by this condition.
Authors
- Xiaoju Zhang (ORCID: https://orcid.org/0000-0001-7040-5490)
- Zheng Li (ORCID: https://orcid.org/0000-0001-8935-9359)
- Weixia Xuan
- Chaofan Liang
- Xu Wu (ORCID: https://orcid.org/0000-0002-1624-0143)
- Shenying Yang
Institutions
- Hunan Normal University (CN)
- Henan University (CN)
- Capital Medical University (CN)
- China-Japan Friendship Hospital (CN)
- Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
- Hunan Provincial People's Hospital (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1097/cm9.0000000000003447
- Citations
- 3
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06