Establishment and Characterization of a Brain Parenchymal Metastatic Cell Line <scp>AlmoR1</scp> Derived From an <scp>NSCLC</scp> Patient With <scp>EGFR</scp>‐<scp>TKI</scp> Resistance
These data suggest that the established cell line, AlmoR1, preserved the resistance to broad third-generation EGFR-TKIs and good tumorigenicity in an intracranial orthotopic model, so that it can serve as a new tool to elucidate the pathogenesis, explore new treatment methods, and conduct the development of new drugs for targeted therapy resistance of brain metastases.
Authors
- Zide Chen
- Guoying Feng
- Xinglong Wu (ORCID: https://orcid.org/0000-0003-4373-2511)
- Rong Wang (ORCID: https://orcid.org/0000-0002-0465-9561)
- Yuhan Wang (ORCID: https://orcid.org/0009-0001-7859-8394)
- Jing Wang (ORCID: https://orcid.org/0000-0002-5398-0802)
- Wei Wang (ORCID: https://orcid.org/0000-0001-8700-364X)
- Jingyi Wu (ORCID: https://orcid.org/0000-0003-0047-6378)
Institutions
- Nanfang Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Guangdong 999 Brain Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/cam4.70827
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Nanfang Hospital