HPV11E6/E7 induces nasal epithelial hyperplasia through JAK2/STAT3 signaling pathway
In summary, we found that low-risk subtype HPV11 promotes nasal mucosal epithelial hyperplasia and malignant progression by increasing activation of the JAK2/STAT3 pathway. The JAK2/STAT3 pathway has been prioritized due to its established role in promoting cell proliferation and EMT in HPV-related diseases.
Authors
- Shuixian Huang (ORCID: https://orcid.org/0000-0002-0381-8508)
- Enhui Zhou (ORCID: https://orcid.org/0000-0001-8252-7778)
- Baoji Hu (ORCID: https://orcid.org/0000-0001-6768-7984)
- Yi Zhang (ORCID: https://orcid.org/0000-0003-1539-7322)
- Xiaocheng Xue
- Runyu Zhao (ORCID: https://orcid.org/0000-0003-2643-0685)
- Wenhao Yao (ORCID: https://orcid.org/0000-0002-2448-3321)
- Tian Kaisai (ORCID: https://orcid.org/0000-0002-2748-8347)
- Xiaoping Chen (ORCID: https://orcid.org/0000-0003-3048-2699)
- Liying Zheng (ORCID: https://orcid.org/0000-0003-2073-4194)
- Gui-fang Zhu
Institutions
- University of Shanghai for Science and Technology (CN)
- Second Military Medical University (CN)
- Shanghai Chest Hospital (CN)
- Pudong Medical Center (CN)
- Ningxia Medical University (CN)
- Shanghai Pudong New Area Gongli Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1186/s40001-025-02496-5
- Citations
- 1
- Primary Topic
- Head and Neck Surgical Oncology
- Type
- article
- Field-Weighted Citation Impact
- 2.01