Annexin A1/FPR2 pathway modulates leukocyte function during <scp><i>Escherichia coli</i></scp>‐induced pneumonia to promote resolution of inflammation and restores lung function
In summary, these findings highlight the role for ANXA1/FPR2 pathway as a nonredundant resolution mechanism for E. coli-induced pneumonia and demonstrate that annexin I-(2-26) as a potential host-directed therapeutic approach to treat infectious lung diseases.
Authors
- Remo Castro Russo (ORCID: https://orcid.org/0000-0002-1715-3834)
- Luciana P. Tavares (ORCID: https://orcid.org/0000-0002-5319-0210)
- Mauro Perretti (ORCID: https://orcid.org/0000-0003-2068-3331)
- Isabella Zaidan (ORCID: https://orcid.org/0000-0001-9434-8814)
- Lirlândia P. Sousa (ORCID: https://orcid.org/0000-0002-1042-9762)
- Celso Martins Queiroz‐Junior (ORCID: https://orcid.org/0000-0002-7884-7709)
- Mauro Martins Teixeira (ORCID: https://orcid.org/0000-0002-6944-3008)
- A. Monteiro (ORCID: https://orcid.org/0009-0001-8334-1219)
- Érick Bryan de Sousa Lima (ORCID: https://orcid.org/0000-0003-2052-2976)
- Lívia Cristina Ribeiro Teixeira (ORCID: https://orcid.org/0000-0002-5817-7808)
- Camila Cardoso (ORCID: https://orcid.org/0000-0001-8131-579X)
- Fernanda S. Carneiro (ORCID: https://orcid.org/0000-0002-5776-1519)
- Antônio Felipe Silva Carvalho (ORCID: https://orcid.org/0000-0001-6185-274X)
- Ana Clara M. Montuori‐Andrade (ORCID: https://orcid.org/0000-0002-1864-4838)
- Vivian Vasconcelos Costa (ORCID: https://orcid.org/0000-0002-0175-642X)
- Laís C. Grossi
- Rodrigo Severo Caixeta
- Edvaldo S. Lara
- Isabella L. Augusto
Institutions
- Universidade Federal de Minas Gerais (BR)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Queen Mary University of London (GB)
- William Harvey Research Institute (GB)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/bph.70026
- Citations
- 3
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais