Combination Therapy versus Monotherapy in Treatment of Arterial Hypertension

Hypertension is the most prevalent cardiovascular disorder and is linked to elevated mortality rates. Blood pressure is controlled by complex neural, endocrine, renal and blood vessels. Hypertension is classified into primary and secondary hypertension Blood pressure is equal to peripheral vascular resistance multiply by cardiac output. Different drugs have been used in the treatment of hypertension each with different mechanism of action and adverse effects such as diuretic drugs, angiotensin converting enzyme inhibitor, vasodilators, centrally acting antihypertension drugs. Monotherapy of hypertension with single drug is ineffective in controlling high blood pressure therefore combination therapy with two of three drugs is usually effective as each drug acting with different mechanism of action and different site this leading to better blood pressure control.