Evidence-based advances skin cancer screening with retrate project: innovative approaches to melanoma early detection

Conclusions: DiscussionIn our cohort of patients with non-small CMN, all cutaneous melanomas (CM) were detected during dermatological follow-up as low-risk melanomas during adulthood.Extracutaneous melanoma (EM) developed both in early infancy as well as adulthood, with frequently fatal outcomes.Despite 91% of our nsCMN cohort having classical CMN, 50% of melanomas occurred in patients with spilus and agminated subtypes of CMN.Partial excisions during infancy did not impact the development of both CM and EM.Limitations: selection bias due to its setting in a referral melanoma unit and exclusion of patients with CM located outside the nsCMN.Conclusions: patients with non-small CMN are at risk of developing cutaneous melanoma, mainly in adulthood, while extracutaneous melanomas can appear throughout life, including infancy, and typically have a somber prognosis.Non-small CMN patients require lifelong dermatologic follow-up.