First Description of Triple Co-Localization Using x400 Super-Magnified Dermoscopy, LC-OCT, and x20 Dermoscopy

Results: Comparable cells were observed in LC-OCT as large cells with a peripheral hyper-reflective ring located along the dermoepidermal junction and within the dermis This case illustrates strong correlation between non-invasive skin imaging findings and histology.The presence of multinucleated giant cells, typically associated with histiocytic lesions, has also been described in "fibroxanthome-like" or "xanthogranulome-like" melanomas and Spitz nevi.This highlights the critical role of immunohistochemical staining in cases of diagnostic uncertainty to confirm the malignant melanocytic nature of the lesion.Conclusions: Although multinucleated giant cells have previously been observed in LC-OCT imaging of xanthogranulomatous lesions, this represents, to our knowledge, the first description of a giant cell melanoma in LC-OCT.It is a rare tumor that must not be misdiagnosed as a benign histiocytic lesion.