The Role of 68Ga-DOTA-G2-Nle-MSH PET in Enhancing Specificity for Melanoma Detection: Case Reports

Results: Comparable cells were observed in LC-OCT as large cells with a peripheral hyper-reflective ring located along the dermoepidermal junction and within the dermis This case illustrates strong correlation between non-invasive skin imaging findings and histology.The presence of multinucleated giant cells, typically associated with histiocytic lesions, has also been described in "fibroxanthome-like" or "xanthogranulome-like" melanomas and Spitz nevi.This highlights the critical role of immunohistochemical staining in cases of diagnostic uncertainty to confirm the malignant melanocytic nature of the lesion.Conclusions: Although multinucleated giant cells have previously been observed in LC-OCT imaging of xanthogranulomatous lesions, this represents, to our knowledge, the first description of a giant cell melanoma in LC-OCT.It is a rare tumor that must not be misdiagnosed as a benign histiocytic lesion.

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Journal
EJC Skin Cancer
Published
2025-01-01
DOI
https://doi.org/10.1016/j.ejcskn.2025.100414
Primary Topic
Medical Imaging Techniques and Applications
Type
article
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article

The Role of 68Ga-DOTA-G2-Nle-MSH PET in Enhancing Specificity for Melanoma Detection: Case Reports

Eduardo Savio, Javier Giglio, Dahiana Amarillo, Vanessa Devens Trindade et al.
EJC Skin Cancer
Medical Imaging Techniques and Applications
article

The Role of 68Ga-DOTA-G2-Nle-MSH PET in Enhancing Specificity for Melanoma Detection: Case Reports

Eduardo Savio, Javier Giglio, Dahiana Amarillo, Vanessa Devens Trindade, Gabriel Krygier, Florencia Savio, Edilberto R. Silveira, Paulo Schiavom Duarte, Ómar Alonso, Marcos Tassano, María del Carmen Cabrera, Juan Pablo Gambini, Miguel Camblor, T. Taglialiar, F. Gentini
article en

Abstract

Results: Comparable cells were observed in LC-OCT as large cells with a peripheral hyper-reflective ring located along the dermoepidermal junction and within the dermis This case illustrates strong correlation between non-invasive skin imaging findings and histology.The presence of multinucleated giant cells, typically associated with histiocytic lesions, has also been described in "fibroxanthome-like" or "xanthogranulome-like" melanomas and Spitz nevi.This highlights the critical role of immunohistochemical staining in cases of diagnostic uncertainty to confirm the malignant melanocytic nature of the lesion.Conclusions: Although multinucleated giant cells have previously been observed in LC-OCT imaging of xanthogranulomatous lesions, this represents, to our knowledge, the first description of a giant cell melanoma in LC-OCT.It is a rare tumor that must not be misdiagnosed as a benign histiocytic lesion.

EJC Skin CancerVol. 3
Universidad de la República de Uruguay (UY), Hospital de Clínicas (UY), Centro Uruguayo de Imagenología Molecular (UY)
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Openalex Percentile: Top 90%
Medical Imaging Techniques and Applications
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