Illuminating In Vitro Melanocyte Transformation: The Role of UV Radiation in Melanomagenesis

Densely pigmented hyphae in the nail plate.Hematoxylin and eosin staining, 40x.Dermoscopy of the nail plate revealing area of irregular, asymmetric pigmentation with multiple colors.Conclusions: Although Tinea Nigra is more frequent in tropical regions, it is crucial to expand awareness of this mycosis, its clinical presentation, and its differential diagnoses.The rarity of reports on the mimicry of acral melanoma by Tinea Nigra underscores the relevance of this study, given the potential severity of a misdiagnosis.Such errors could lead to unnecessary surgical interventions and significant psychological distress for patients.In the presented case, the patient's advanced age, subungual lesion, and dermoscopic findings-characterized by irregular pigmentation, asymmetry, and multiple colors-compounded the diagnostic challenge.This case highlights the need to include Tinea Nigra in the differential diagnosis of acral pigmented lesions and underscores the critical role of expert pathologists in slide analysis to prevent false diagnoses of acral melanoma.