Effectiveness of an Autologous Filler in Patients with Moderate to Severe Nasolabial Folds: A Pilot Study

<b>Background:</b> Nasolabial folds, commonly known as smile lines, are a cosmetic concern for individuals. <b>Objective:</b> To measure the change in facial volume at the nasolabial folds among adults injected with an autologous blood filler, as measured by three-dimensional (3D) photography and aesthetic surveys. <b>Methods:</b> Fifteen participants above the age of 22 received up to three autologous filler injections, to bilateral nasolabial folds, over a 24-week treatment period. Based on investigator's discretion, injections ranged from 0.6 to 3.0 cc at the initial visit, week 4, and week 16. Follow-ups were conducted at weeks 2, 6, 8, 20, and 24 with measurements completed at the beginning of each treatment and follow-up visit. Standardized 3D photography with Vectra® and QuantifiCare® cameras measured volume for before and after comparison. Patients and investigator completed the Wrinkle Severity Rating Scale and Global Aesthetic Improvement Scale. <b>Results:</b> Fifteen patients, 1 male and 14 female, age 32-63, were followed-up for 24 weeks. The treatment improved nasolabial fold appearances and patient satisfaction. The 3D imaging revealed increased volume in the treated areas. <b>Conclusion:</b> The autologous filler effectively fills moderate-to-severe nasolabial folds in this pilot study and future studies are needed to evaluate safety.