Single-cell multiomics identifies central memory immunologic phenotypes in CTCL - transition from blood to skin

Background: Cutaneous T-cell lymphoma (CTCL) is a malignancy characterised by neoplastic lymphocytes accumulating in the skin. In patients with the aggressive Sézary Syndrome, malignant T-cells are detected in both the blood circulation and skin lesions. Therefore, different phenotypes of T-cells can be studied in both local cutaneous and systemic environments. Circulating T-cells extravasate and accumulate in the skin where they form an immunologic memory. Using skin and blood of CTCL patients, we studied the influence of skin microenvironment on the initiation of malignant T-cell homing, memory formation and their immunological function.