RvD2 mitigates TNFɑ-Induced mitochondrial reactive oxygen species through NRF2 signaling in placental trophoblasts
These findings demonstrate that RvD2 functions as a positive regulator of endogenous antioxidant properties by enhancing NRF2 levels and mitigating mitochondrial ROS in placental trophoblasts.
Authors
- Chandan Krishnamoorthy (ORCID: https://orcid.org/0000-0001-5909-3107)
- Sankar Ramamurthy
- Corrine Hanson (ORCID: https://orcid.org/0000-0002-5118-591X)
- Anum Akbar (ORCID: https://orcid.org/0000-0001-8439-7671)
- Aiswariya Ravi
- Rebekah Rapoza (ORCID: https://orcid.org/0009-0002-6954-0059)
- Colman Freel (ORCID: https://orcid.org/0000-0003-0820-1221)
- Taija Hahka (ORCID: https://orcid.org/0000-0002-0076-4604)
- Sathish Kumar Natarajan (ORCID: https://orcid.org/0000-0001-7491-8592)
- Melissa Thoene (ORCID: https://orcid.org/0000-0001-8554-0708)
- Tara M. Nordgren (ORCID: https://orcid.org/0000-0001-6398-8528)
- Matt VanOrmer
- Prakash Kumar Sahoo
- Ann Anderson Berry
- Rebecca Drakowski
- Deekshika Sekar
Institutions
- University of Nebraska–Lincoln (US)
- Nebraska Medical Center (US)
- University of Nebraska Medical Center (US)
- Colorado State University (US)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-04-02
- DOI
- https://doi.org/10.3389/fphys.2025.1547940
- Citations
- 2
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 4.11