New Advances in the Construction of Amide Compounds

酰胺键的形成是有机化学中最重要的反应之一。因为酰胺类广泛存在于现代药物和生物活性物质中，然而酰胺键的合成作为当代的挑战经常被忽视。早期合成酰胺的方法有着它们固有的局限性，反应简单快速、方法的普适性越来越受到人们的重视，开发新颖的形成酰胺键的化学方法势在必行。在合成酰胺键的许多方法中，利用催化方法来制备这类重要的官能团备受人们关注，其中金属催化与光催化反应的应用得到广泛关注。催化剂用于形成酰胺键已成为在关键领域中一些最新文献的亮点。醇、醛、羧酸作为底物和有机胺在各种条件下反应得到相应的酰胺。回顾并总结酰胺的合成方法有助于解决目前工艺中存有的问题。The formation of amide bonds is one of the most important reactions in organic chemistry. Because amides are widely found in modern pharmaceuticals and bioactives, the synthesis of amide bonds is often overlooked as a contemporary challenge. The early methods of synthesizing amides have their inherent limitations, and the simple and rapid reaction and the universality of the method have attracted more and more attention, and it is imperative to develop novel chemical methods for the formation of amide bonds. Among the many methods for the synthesis of amide bonds, the use of catalytic methods to prepare these important functional groups has attracted much attention, among which the application of transition metal catalysis and photocatalytic reaction has received extensive attention. The use of catalysts for the formation of amide bonds has been the highlight of some of the latest literature in key areas. Alcohols, aldehydes, carboxylic acids and organic amines are reacted as substrates to obtain corresponding amides under various conditions. Reviewing and summarizing the synthesis methods of amides can help to solve the problems existing in the current process.