Testosterone Effects on Short-term Physical, Hormonal, and Neurodevelopmental Outcomes (TESTO) in Infants With 47,XXY
In this double-blind randomized controlled trial in infants with XXY, testosterone injections resulted in physical effects attributable to systemic androgen exposure; however, this dose suppressed the hypothalamic-pituitary-gonadal axis. Neurodevelopment outcomes were not impacted by treatment. These results do not support routine testosterone treatment in infants with XXY; however, long-term follow-up on physical health, neurodevelopment, and testicular function is needed.
Authors
- Philip Zeitler (ORCID: https://orcid.org/0000-0001-5756-7858)
- Karli S. Swenson (ORCID: https://orcid.org/0000-0003-0513-7308)
- Shanlee Davis (ORCID: https://orcid.org/0000-0002-0304-9550)
- Nicole Tartaglia (ORCID: https://orcid.org/0000-0002-8529-6722)
- Regina Romano Reynolds (ORCID: https://orcid.org/0000-0001-8016-9145)
- Jennifer Janusz (ORCID: https://orcid.org/0000-0002-6877-0947)
- Talia Thompson (ORCID: https://orcid.org/0000-0001-6512-9743)
- Susan Howell (ORCID: https://orcid.org/0000-0001-7115-2165)
- Judith L. Ross (ORCID: https://orcid.org/0000-0002-8613-2498)
- Najiba Lahlou (ORCID: https://orcid.org/0000-0003-1365-6466)
- Rebecca Wilson (ORCID: https://orcid.org/0000-0003-0464-229X)
Institutions
- Community Health Systems - Dupont Hospital (US)
- Children's Hospital Colorado (US)
- Nemours Children's Health System (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1210/clinem/dgaf217
- Citations
- 2
- Primary Topic
- Sexual Differentiation and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61