STEROIDAL THIOSEMICARBAZONES: DRUG-LIKENESS AND ANTIOXIDANT PROPERTIES

Thiosemicarbazones (TSCs) are well known for their diverse biological activities and wide-ranging applications. This study assessed the drug- likeness and antioxidant potential of previously synthesized steroidal TSCs with promising cytotoxicity. While all tested androstane TSCs are drug-like, they have poor water solubility, strong plasma protein binding ability, and low blood-brain barrier permeability. Mono-TSCs show better absorption parameters, but bis- TSCs are stronger antioxidants, with compound 4 being 4.5 times more active than ascorbic acid. All tested TSCs could be considered potential cytotoxic and antioxidant agents.