Effective Treatment of highly proliferative AK with Tirbanibulin: A Case Report
Background: Actinic keratoses (AKs) are precancerous skin lesions, which can progress to cutaneous squamous cell carcinoma (cSCC).1Treatment options range from (cryo)surgical interventions to ablative lasers, topicals, and photodynamic therapies.1 However, some AKs show resistance to conventional therapies possibly due to varying proliferation patterns.The proliferation score (PRO) is a histological tool used to describe AKs proliferation behavior at the epithelium's basal layer. Classifying AKs into three stages (PRO I, II, III) based on their basal growth patterns:
Authors
- Thomas Dirschka (ORCID: https://orcid.org/0000-0001-7804-5311)
- Lutz Schmitz (ORCID: https://orcid.org/0000-0002-9627-2179)
- Marcus Kuchner
- P. Melzer
Publication Details
- Journal
- EJC Skin Cancer
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.ejcskn.2025.100307
- Citations
- 1
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.80