Impact of tumor localization on antitumor immunity with conditionally activated CTLA-4 blockade
These findings support the notion that ICB modulation of antitumor immunity away from the tumor cells is critically important for optimal antitumor immunity. The bispecific sDVD antibody design may enable improved systemic antitumor responses than traditional ICB in both primary tumors and metastases.
Authors
- Yee May Lwin
- Elizabeth A. Musser
- Jacob V. Gorman
- Wendy Ritacco
- Peixi Chen (ORCID: https://orcid.org/0000-0002-7584-4609)
- Marcel Arias-Badia (ORCID: https://orcid.org/0000-0003-2270-0676)
- Lawrence H. Fong (ORCID: https://orcid.org/0000-0002-6428-428X)
- Chien-Chun Steven Pai
- Aahir Srinath
- Miho Tanaka (ORCID: https://orcid.org/0000-0002-0905-9346)
- Andrew Goodearl
Institutions
- University of California, San Francisco (US)
- AbbVie (United States) (US)
- Fred Hutch Cancer Center (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/jitc-2024-010566
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AbbVie