Lifetime estrogen exposure and domain-specific cognitive performance: results from the IGNITE study
Our results suggest exposure to estrogen during adulthood, specifically birth control and hormone therapy among women undergoing pre-menopausal oophorectomy, benefits cognitive function in older adulthood. Our comprehensive cognitive battery allowed us to examine cognitive function with a high degree of granularity. Future work should evaluate causal mechanisms of associations between lifetime estrogen exposure and later life cognitive function.
Authors
- Shannon D. Donofry (ORCID: https://orcid.org/0000-0002-7394-1384)
- Kirk I. Erickson (ORCID: https://orcid.org/0000-0001-8736-981X)
- George Grove (ORCID: https://orcid.org/0000-0002-5043-139X)
- Eric D. Vidoni (ORCID: https://orcid.org/0000-0001-5181-7131)
- Edward McAuley (ORCID: https://orcid.org/0000-0002-4574-3292)
- Lauren E. Oberlin (ORCID: https://orcid.org/0000-0001-9553-8070)
- Arthur F. Kramer (ORCID: https://orcid.org/0000-0001-5870-2724)
- Swathi Gujral (ORCID: https://orcid.org/0000-0003-4775-2106)
- Charles H. Hillman (ORCID: https://orcid.org/0000-0002-3722-5612)
- Nicole M. Eklund (ORCID: https://orcid.org/0000-0001-5578-519X)
- Jeffrey Murray Burns (ORCID: https://orcid.org/0000-0001-7609-8954)
- Amber Watts (ORCID: https://orcid.org/0000-0002-8385-1091)
- M. Ilyas Kamboh (ORCID: https://orcid.org/0000-0002-3453-1438)
- Hayley S. Ripperger
- Chaeryon Kang (ORCID: https://orcid.org/0000-0001-9442-8515)
- Lu Wan
Institutions
- Boston University (US)
- Boston Medical Center (US)
- Northeastern University (US)
- RAND Corporation (US)
- University of Kansas (US)
- University of Illinois Urbana-Champaign (US)
- University of Pittsburgh (US)
- Cornell University (US)
- AdventHealth Orlando (US)
- Adventist University of Health Sciences (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-04-03
- DOI
- https://doi.org/10.3389/fnagi.2025.1524474
- Citations
- 4
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.18
Funders
- National Institutes of Health